HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-5-fluorobenzonitrile → 3-Fluoro-5-(2,2,4,4-tetramethyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-5-fluorobenzonitrile | HCID 2783330 | — |
| Reactant | HCID 23435577 | HCID 23435577 | — |
| Product | 3-Fluoro-5-(2,2,4,4-tetramethyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-benzonitrile | HCID 18374561 | — |
Reaction Steps
Prepared using the coupling procedure for Example 13 starting with 6-bromo-2,2,4,4-tetramethyl-1,4-dihydro-2H-3,1-benzoxazine and 3-bromo-5-fluorobenzonitrile. A white solid: 1H-NMR (DMSO-d6) δ 8.03 (s, 1H), 7.87 (d, 1H, J=10.7 Hz), 7.65 (d, 1H, J=10.7 Hz), 7.57 (d, 1H, J=1.98 Hz) 7.45 (dd, 1H, J=8.33, 1.98 Hz), 6.65 (d, 1H, J=8.33 Hz), 6.42 (s, 1H), 1.52 (s, 6H), 1.34 (s, 6H); MS (ES) m/z 311 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358948B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-069f3985f6da487fb7f399b4061769ea |
| Source note | uspto-grants-2002_03 |