HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(3-Methoxy-phenyl)-8-phenyl-octan-nitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (3-Methoxyphenyl)acetonitrile | HCID 88310 | — |
| Reactant | 6-Phenylhexyl tosylate | HCID 10688038 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3-Methoxy-phenyl)-8-phenyl-octan-nitrile | HCID 22626842 | 54.1% |
Reaction Steps
By working in a way similar to that described in example 2 but using toluen-4-sulphonic acid 6-phenyl-hexyl ester (5.4 g, 16.24 mmoles), obtained as described in example 11, 3-methoxy-phenyl-acetonitrile (2.39 g, 16.24 mmoles), NaH (55-65%, 715 mg, 17.86 mmoles) and DMF (25 ml), 2.7 g of the title compound were obtained (yield: 54.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358973B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-dc215c38cfb646fe9e1b32025bde5c34 |
| Source note | uspto-grants-2002_03 |