HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 277921Generated: October 28, 2026
Ammonia → (6-Aminopyridin-3-yl)(phenyl)methanone
https://huagongshe.com/reaction/277921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanone, (6-chloro-3-pyridinyl)phenyl- | HCID 3061713 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (6-Aminopyridin-3-yl)(phenyl)methanone | HCID 13015392 | — |
Reaction Steps
The 2-chloro-5-benzoylpyridine (100 g, 0.460 mol) was dissolved in 500 ml of 3A EtOH and 400 ml of anhydrous ammonia, placed in a bomb, then heated at 145° C. for 16 hours. The solvents were removed in vacuo and the remaining tan solid was recrystallized from EtOH/H2O yielding 77.4 g (85%) of product as a tan solid. EA, MS(FD).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06358971B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-fbad836a3d4e4655908c7d0d9f740b7e |
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| Source note | uspto-grants-2002_03 |
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