HCID 10904968, compound → HCID 22626712, compound

Participants

Reaction Steps

The 2-trifluoroacetamido-3-methylthio-6-benzoyl-imidazo[1,2-a]pyridine (100 mg, 263 mmol) was dissolved in 20 mL of a mixture of MeOH/CH2Cl2 1:1, and 5 g of silica gel was added. The mixture was stirred at RT for 2 days. The residue was filtered and washed with CH2Cl2 and the solution was concentrated in vacuo to give 63 mg (850%) of a yellow solid. 1H-NMR (200 MHz, CDCl3) d 2.12 (s, 3H, SMe), 4.40 (bs, 2H, NH2), 7.46-7.80 (m, 7H, ArH+H7+H8), 8.68 (d, J57=1.7, H5). 13C-NMR (50 MHz, CDCl3) d 18.0 (SMe), 95.0, 122.7, 125.8, 127.7, 128.5, 129.6, 132.6, 137.4, 145.3, 156.1, 193.5.

Provenance & Evidence