1-Bromo-3-fluorobenzene → 2-Amino-3-phenyl-6-(3-fluorobenzoyl)-imidazo[1,2-a]pyridine

Participants

Reaction Steps

The 2-amino-3-phenyl-6-(N-methyl-N-methoxycarbamoyl)imidazo[1,2-a]pyridine (148 mg, 0.500 mmol) and 1-bromo-3-fluorobenzene were converted to product in a manner substantially analogous to Example 141 to give 37 mg. (37%). MS(FAB+) m/z 332.2 (M++1, 86.6), NMR (200 MHz, CDCl3) d 4.22 (bs, 2H, NH), 7.21-7.55 (m, 11H, ArH+H7+H8), 8.69 (d, J57=1.1, H5).

Provenance & Evidence