1-Bromo-4-fluorobenzene → 2-Amino-3-phenyl-6-(4-fluorobenzoyl)-imidazo[1,2-a]pyridine

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Reaction Steps

The 2-amino-3-phenyl-6-(N-methyl-N-methoxycarbamoyl)imidazo[1,2-a]pyridine (584 mg, 1.97 mmol) and 1-bromo-4-fluorobenzene were converted to product in a manner substantially analogous to Example 141 to yield 205 mg. (52%). NMR (200 MHz, CDCl3) d 4.31 (bs, 2H, NH), 7.15 (m, 2H, F—ArH ), 7.25-7.56 (m, 7H, ArH+H7+H8), 7.78 (m, 2H, F—ArH), 8.69 (s, H5).

Provenance & Evidence