HCID 16097175, compound → HCID 22626323, compound

Participants

Reaction Steps

To a solution of 2′-benzyloxycarbonyl-4′-nitro-2-biphenylcarboxylic acid (2.08 g) which was prepared by the same procedure as a series of reaction of Reference Example 4→Reference Example 5, using Benzyl 2-trifluoromethylsulfonyloxy-5-nitrobenzoate, in concentration hydrochloric acid-ethanol (5:3, 8 ml), a solution of Tin (II) chloride dihydrate (3.7 g) in ethanol (5 ml) was added. The mixture was stirred for 1 hour at room temperature. 2N aqueous solution of sodium hydroxide was added to the reaction solution, the solution was extracted with ethyl acetate (2 times). The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (Chloroform:Methanol:Water=9:1:0.1→8:2:0.2) to give the title compound (1.07 g) having the following physical data.

Provenance & Evidence