Azido(trimethyl)stannane → HCID 178525022, compound

Participants

Reaction Steps

To a solution of benzyl 2′-cyano-2-bipheylcarboxylate (560 mg) in toluene (10 ml), azidotrimethyltin (810 mg) was added. The mixture was refluxed for 12 hours. The reaction mixture was concentrated. 5% aqueous solution of potassium fluoride (4 ml) was added to the residue. The solution was filtered. The filtrate was diluted with ethyl acetate, and the solution was washed with a saturated aqueous solution of sodium chloride. The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1→chloroform:methanol=10:1) to give the title compound (545 mg) having the following physical data.

Provenance & Evidence