Triethylamine → 2-Methoxy-5-Nitro-6-(2-Dimethylaminoethen-1-yl)pyridine

Participants

Reaction Conditions

Reaction Steps

To 2-methoxy-5-nitro-6-methylpyridine (29.39 g, 175 mmol) dissolved in 300 mL of N,N-dimethylformamide was added dimethylformamide dimethylacetal (120 mL, 896 mmol) and triethylamine (1 mL). The bright red reaction mixture was heated at 120° C. for 2 hours, then concentrated in vacuo to provide 38.90 g of the title compound as a red solid, which was used in Preparation 13 without further purification.

Provenance & Evidence