4-Fluoro-1-naphthaleneboronic Acid (contains varying amounts of Anhydride) → 5-(4-Fluoronaphth-1-yl)-3-(1-Methylpiperidin-4-yl)-4-Aza-1H-Indole

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Reaction Steps

O-Trifluoromethanesulfonyl-3-(1-methylpiperidin-4-yl)-5-hydroxy-4-aza-1H-indole (160 mg, 0.441 mmol) and 4-fluoronaphth-1-ylboronic acid (134 mg, 0.71 mmol) were converted to 134 mg of the title compound by the procedure of Example 3. (85%). MS(FD) m/e 359.8 (M+). EA calculated for C23H22FN3: C, 76.88; H, 6.13; N, 11.70. Found: C, 77.15; H, 6.21; N, 11.62.

Provenance & Evidence