p-Bromoacetophenone → HCID 9797677, compound

Participants

Reaction Steps

The title compound was prepared by the procedure of Example 10, beginning with 3-(1-methylpiperidin-4-yl)-1H-indole-5-boronic acid (0.200 g, 0.77 mmol), 1-bromo-4-acetylbenzene (0.147 g, 0.74 mmol), tetrakis(triphenylphosphine)palladium(O) (0.045 g, 0.039 mmol), and 2M aqueous sodium carbonate solution (2 mL) in 15 mL of tetrahydrofuran:methanol (1:1) to give the title compound (0.171 g, 70%) as an amorphous solid. FDMS m/e=348 (M+). EA calculated for C22H24N2O.¼ H2O: C, 78.19; H, 7.31; N, 8.29. Found: C, 78.00; H, 7.27; N, 7.93.

Provenance & Evidence