1-Fluoro-4-methoxy-2-vinylbenzene → 2-Ethyl-1-fluoro-4-methoxybenzene

Participants

Reaction Steps

To a solution of 9 g of 3-ethenyl-4-fluoroanisole in 200 ml of ethanol was added 0.9 g of palladium/carbon. The resulting mixture was stirred under hydrogen atmosphere overnight, and filtered through Celite. The filtrate was evaporated, and the resulting residue was subjected to silica gel column chromatography (developer: 50% ethyl acetate/n-hexane) to give 7.0 g of the title compound as a colorless oil.

Provenance & Evidence