Potassium Hydroxide → HCID 22627677, compound

HRID 278061Notes

Reaction equation

HRID 278061 reaction equation
[CH:1]([S:4][C:5]([CH3:12])([CH3:11])[C:6]([O:8]CC)=[O:7])([CH3:3])[CH3:2].[OH-].[K+]>C(O)C.O>[CH:1]([S:4][C:5]([CH3:12])([CH3:11])[C:6]([OH:8])=[O:7])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 22627680HCID 22627680, compound

Product 1

HCID 22627677HCID 22627677, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of ethyl 2-(isopropylthio)-2-methylpropionate (5.4 g, 30 mmol) and potassium hydroxide (5.0 g, 90 mmol) in ethanol is refluxed for 6 hours, cooled, and concentrated in vacuo to obtain a residue. The residue is diluted with water, washed with ether, acidified with hydrochloric acid, and extracted with ether. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. The solid is washed with chloroform and dried under reduced pressure to give the title product as a solid, mp 51.5-52.5° C.

Workup

  1. temperatureis refluxed for 6 hours
  2. temperaturecooled
  3. concentrationconcentrated in vacuo
  4. customto obtain a residue
  5. washwashed with ether
  6. extractionextracted with ether
  7. washThe combined organic extracts are washed sequentially with water and brine
  8. dry with materialdried over anhydrous magnesium sulfate
  9. concentrationconcentrated in vacuo
  10. customto obtain a solid
  11. washThe solid is washed with chloroform
  12. customdried under reduced pressure

Sources & evidence

ORD record
ord-0e9ebb424c524824b57dba70cf1006b6
Source dataset
uspto-grants-2002_03
Patent number
US06359009B1

Reaction notes

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