Acetyl chloride → HCID 22627215, compound

HRID 278073Notes

Reaction equation

[CH2:1]([C:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16][CH3:17])=[O:15])=[CH:11][CH:12]=2)[NH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([C:6]1[NH:7][C:8]2[C:13]([C:5]=1[CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH3:17])=[O:15])[CH:9]=2)(=[O:20])[CH3:19]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 22627286HCID 22627286, compound

Product 1

HCID 22627215HCID 22627215, compound

Procedure

Methyl 2-acetyl-3-isobutylindole-6-carboxylate (43 mg) was prepared from methyl 3-isobutylindole-6-carboxylate (99 mg) and acetyl chloride (0.073 ml) in a similar manner to that of Preparation 1 (5).

Sources & evidence

ORD record: ord-12dbfc43a55d4e25b1596591ee00c112
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06358992B1

Reaction notes

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