참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Methyl 5-hexynoate | HCID 534077 | — |
| 반응물 | Methyl 3-acetamido-4-trifluoromethanesulfonyloxybenzoate | HCID 14493070 | — |
| 촉매 | Triphenylphosphine | HCID 11776 | — |
| 촉매 | Palladium Chloride | HCID 24290 | — |
| 용매 | Diethylamine | HCID 8021 | — |
| 생성물 | Methyl 3-acetamido-4-(5-methoxycarbonyl-1-pentynyl)benzoate | HCID 22627137 | 86.5% |
반응 단계
A mixture of methyl 3-acetamido-4-trifluoromethane-sulfonyloxybenzoate (1.43 g), methyl 5-hexynoate (582 mg), palladium(II) chloride (14 .9 mg), triphenylphosphine (43.8 mg) and cooper(I) chloride (32 mg) in diethylamine (18 ml) was stirred at 20° C. for 14 hours. The solvent was evaporated in vacuo an the residue was chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate (1:2) to give methyl 3-acetamido-4-(5-methoxycarbonyl-1-pentynyl)-benzoate (1.15 g) as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06358992B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_03 |
|---|
| ORD ID | ord-28b80c2cdc5a4419813945f88a1a28ba |
|---|
| 출처 메모 | uspto-grants-2002_03 |
|---|
