反应详情

温度

20 °C

To a stirred solution of methyl 3-ethylindole-6-carboxylate (138 mg) in dichloromethane (5 ml) was added sulfuryl chloride (0.066 ml), and the mixture was stirred at 20° C. for 1 hour. The resulting mixture was poured into ice and extracted with ethyl acetate. The combined organic phase was washed with aqueous sodium bicarbonate and brine, then dried over sodium sulfate and evaporated in vacuo. The residue was chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate (4:1) to give methyl 2-chloro-3-ethylindole-6-carboxylate (58.2 mg) as a solid.

1. additionThe resulting mixture was poured into ice
2. extractionextracted with ethyl acetate
3. washThe combined organic phase was washed with aqueous sodium bicarbonate and brine
4. dry with materialdried over sodium sulfate
5. customevaporated in vacuo
6. customThe residue was chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate (4:1)