反应详情

To a solution of methyl 3-acetyl-1-(2-chlorobenzyl)-2-propylindole-6-carboxylate (125 mg) in ethanol (6 ml) was added 1N aqueous sodium hydroxide (0.7 ml), and the mixture was stirred under reflux for 1 hour. The resulting mixture was evaporated in vacuo, and the residue was acidified with 1N hydrochloric acid (0.75 ml) and extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was triturated with isopropyl ether to give 3-acetyl-1-(2-chlorobenzyl)-2-propylindole-6-carboxylic acid (78 mg) as solid.

1. temperatureunder reflux for 1 hour
2. customThe resulting mixture was evaporated in vacuo
3. extractionextracted with ethyl acetate
4. washThe extract was washed with brine
5. dry with materialdried over sodium sulfate
6. customevaporated in vacuo
7. customThe residue was triturated with isopropyl ether