alpha-Bromo-o-chlorotoluene → HCID 10272156, compound

HRID 278105Notes

Reaction equation

HRID 278105 reaction equation
[C:1]([C:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16][CH3:17])=[O:15])=[CH:11][CH:12]=2)[NH:7][C:6]=1[CH2:18][CH2:19][CH3:20])(=[O:4])[CH2:2][CH3:3].[Cl:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24]Br>>[Cl:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][N:7]1[C:8]2[C:13](=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH3:17])=[O:15])[CH:9]=2)[C:5]([C:1](=[O:4])[CH2:2][CH3:3])=[C:6]1[CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627251HCID 22627251, compound

Product 1

HCID 10272156HCID 10272156, compoundYield 115.2%

Procedure

Methyl 1-(2-chlorobenzyl)-3-propionyl-2-propylindole-6-carboxylate (436 mg) was prepared from methyl 3-propionyl-2-propylindole-6-carboxylate (260 mg) and 2-chlorobenzyl bromide (216 mg) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-0ba263bb1a4e4aecbe17213fb177a46c
Source dataset
uspto-grants-2002_03
Patent number
US06358992B1

Reaction notes

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