alpha-Bromo-o-chlorotoluene → HCID 22627236, compound

HRID 278107Notes

Reaction equation

HRID 278107 reaction equation
[C:1]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:10][CH:9]=[C:8]([C:17]([O:19][CH3:20])=[O:18])[CH:7]=2)(=[O:3])[CH3:2].[Cl:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24]Br>>[C:1]([C:4]1[N:5]([CH2:24][C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[Cl:21])[C:6]2[C:11]([C:12]=1[CH2:13][CH:14]([CH3:16])[CH3:15])=[CH:10][CH:9]=[C:8]([C:17]([O:19][CH3:20])=[O:18])[CH:7]=2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627215HCID 22627215, compound

Product 1

HCID 22627236HCID 22627236, compound

Procedure

Methyl 2-acetyl-1-(2-chlorobenzyl)-3-isobutylindole-6-carboxylate (71.4 mg) was prepared from methyl 2-acetyl-3-isobutylindole-6-carboxylate (58 mg) and 2-chlorobenzyl bromide (0.04 ml) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-9d1288d241e7409e9edff3e8138bb7a6
Source dataset
uspto-grants-2002_03
Patent number
US06358992B1

Reaction notes

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