Potassium Carbonate → HCID 22627363, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-isobutyryl-2-propylindole-6-carboxamide (100 mg), 4-chlorobenzyl bromine (113 mg) and potassium carbonate (152 mg) in dimethylformamide (2 ml) was heated at 60° C. or 2 hours, and partitioned between ethyl acetate and water. The organic layer was washed with water and brine, and dried over magnesium sulfate. After evaporation of solvent, the residue was crystallized from a mixture of ethyl acetate and hexane. The crude crystals were recrystallized from a mixture of ethyl acetate and hexane to give 1-(4-chlorobenzyl)-3-isobutyryl-2-propylindole-6-carboxamide (97 mg) as colorless crystals.

Provenance & Evidence