Phenylacetyl chloride → HCID 54503411, compound

HRID 278112Notes

Reaction equation

[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([O:16][CH3:17])=[O:15])[CH:12]=2)[CH:7]=[C:6]1[CH2:18][CH2:19][CH3:20].[C:25]1([CH2:31][C:32](Cl)=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(C1C2C(=CC(C(OC)=O)=CC=2)N(CC2C=CC=CC=2OC)C=1CCC)(=O)C(C)C>>[Cl:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]([O:16][CH3:17])=[O:15])[CH:12]=2)[C:7]([C:32](=[O:33])[CH2:31][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:6]1[CH2:18][CH2:19][CH3:20]

Participants

Reactant 3

HCID 7679Phenylacetyl chloride

HCID 22627144HCID 22627144, compound

HCID 22627293HCID 22627293, compound

Product 1

HCID 54503411HCID 54503411, compoundYield 45%

Procedure

Methyl 1-(2-chlorobenzyl)-3-phenylacetyl-2-propylindole-6-carboxylate (230 mg) was prepared from methyl 1-(2-chlorobenzyl)-2-propylindole-6-carboxylate (380 mg) and phenylacetyl chloride (189 mg) in a similar manner to that of Preparation 1 (5).

Sources & evidence

ORD record: ord-dc16875c77d2435e9f58b87ebd1a45b1
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06358992B1

Reaction notes

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