alpha-Bromo-o-chlorotoluene → HCID 22627300, compound

HRID 278113Notes

Reaction equation

HRID 278113 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([O:15][CH3:16])=[O:14])=[CH:10][CH:11]=2)[NH:6][C:5]=1[CH2:17][CH3:18])(=[O:3])[CH3:2].[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br>>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([O:15][CH3:16])=[O:14])=[CH:10][CH:11]=2)[N:6]([CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[Cl:19])[C:5]=1[CH2:17][CH3:18])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 11905alpha-Bromo-o-chlorotolueneHCID 22627420HCID 22627420, compound

Product 1

HCID 22627300HCID 22627300, compound

Procedure

Methyl 3-acetyl-1-(2-chlorobenzyl)-2-ethylindole-6-carboxylate (170 mg) was prepared from methyl 3-acetyl-2-ethylindole-6-carboxylate (100 mg) and 2-chlorobenzyl bromide (0.06 ml) in a similar manner to that of Example 1.

Sources & evidence

ORD record
ord-6f92b49f14214df2b4aba1fb001dc116
Source dataset
uspto-grants-2002_03
Patent number
US06358992B1

Reaction notes

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