Sodium Hydroxide → HCID 178462263, compound

Participants

Reaction Steps

A solution of compound (i) (0.87 g, 0.0007 M) in 50% DMF/methanol (30 ml) was treated with 1 N NaOH solution (1.7 ml) and stirred at R.T. for 2 hours. Acidification precipitated the product (0.43 g) in 50% yield. T.L.C. 2:1 CHCl3 :MeOH (I2 stain) showed one spot at Rf 0.77. [α]D25° =-4.1° (C=1, AcOH). The NMR was consistent with structure.

Provenance & Evidence