HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(t-Butoxycarbonyl)4-((2-benzyl)tetrazol-5-yl)piperidine → 4-((2-Benzyl)tetrazol-5-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(t-Butoxycarbonyl)4-((2-benzyl)tetrazol-5-yl)piperidine | HCID 18187506 | — |
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | 4-((2-Benzyl)tetrazol-5-yl)piperidine | HCID 18187476 | 94% |
| Product | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
Reaction Steps
A solution of 85 mg (0.25 mmol) of 1-(t-butoxycarbonyl)-4-((2-benzyl)tetrazol-5-yl)piperidine (from Step C) in 2 mL of 1:1 v/v methylene chloride/TFA was stirred at rt for 2 h. The solution was concentrated. Flash chromatography on silica gel using 19:1:0.1 v/v/v methylene chloride/methanol/NH4OH as the Eluant afforded 57 mg (94%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358979B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-f48d7bbaccd24143b898f4ce52a2535b |
| Source note | uspto-grants-2002_03 |