N-Benzylnormechlorethamine → 1-Benzyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	N-Benzylnormechlorethamine	HCID 5928	—
Reactant	Ethyl{[4-(2-butynyloxy)phenyl]sulfonyl}acetate	HCID 11335441	—
Product	1-Benzyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester	HCID 11248049	—

Reaction Steps

1-Benzyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method as outlined in Example 1 (Step 6). Starting from (4-but-2-ynyloxy-benzenesulfonyl)-acetic acid ethyl ester (2 g, 6.73 mmol) and bis-(2-chloro-ethyl)-benzyl amine (2.3 g, 8.8 mmol). Yield 3.33 g (99%); yellow oil; MS: 455.9 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06358980B1
Source dataset	uspto-grants-2002_03
ORD ID	ord-90135ee561ad4f5098ee749f412152b0
Source note	uspto-grants-2002_03