Water → HCID 10890704, compound

Participants

Reaction Steps

0.85 g of the obtained ethyl 2-acetyl-5,7-dioxo-6-(3-methylisooxazol-5-yl)octanoate was dissolved in 5 ml of methanol and 0.32 g of triethylamine was added. The resulting solution was stirred at room temperature for 2 hours and then heated at reflux for 3 hours. After cooling, water was added to the reaction solution to extract with ethyl acetate. The organic layer was washed with saturated salt water and dried over anhydrous magnesium sulfate. The solvent was removed by distillation. The obtained residue was purified on silica gel column chromatography to give 0.27 g of the title compound as a colorless liquid.

Provenance & Evidence