HuagongsheHuagongshe Chemistry Print Report · For research reference only
(s)-1-(5-Methoxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-chloro-benzyl)-piperidin-4-ol → (S)-1-(5-Hydroxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-chloro-benzyl)-piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (s)-1-(5-Methoxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-chloro-benzyl)-piperidin-4-ol | HCID 54036117 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-1-(5-Hydroxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-chloro-benzyl)-piperidin-4-ol | HCID 54190367 | — |
Reaction Steps
The title compound, MS: m/e=374.2 (M+H+) [α]=+32.4° (c=1.0, DMF), >99% e.e. by chiral phase HPLC, was prepared from (S)-1-(5-methoxy-2,3-dihydro-benzofuran-2-ylmethyl)-4-(4-chloro-benzyl)-piperidin-4-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06359138B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-e1680135a36e4bf090430466283af315 |
| Source note | uspto-grants-2002_03 |