4-Benzyl-4-piperidinol → (RS)-4-Benzyl-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

HRID 278422Notes

Reaction equation

HRID 278422 reaction equation
[CH2:1]([C:8]1([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([O:22][C:23]1[CH:24]=[CH:25][C:26]2[O:30][CH:29]([CH2:31]Br)[CH2:28][C:27]=2[CH:33]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:1]([C:8]1([OH:14])[CH2:13][CH2:12][N:11]([CH2:31][CH:29]2[CH2:28][C:27]3[CH:33]=[C:23]([O:22][CH2:15][C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:24]=[CH:25][C:26]=3[O:30]2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 981524-Benzyl-4-piperidinolHCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran

Product 1

HCID 22628367(RS)-4-Benzyl-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

Procedure

The title compound MS: m/e=430.6 (M+H+) was prepared from 4-(benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-a483889782f140d0bdfa5bfecdd5929d
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

Loading…