4-[(4-Fluorophenyl)methyl]piperidin-4-ol → (RS)-4-(4-Fluoro-benzyl)-1-(5-benzyloxy-2 3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

HRID 278423Notes

Reaction equation

HRID 278423 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][C:7]2([OH:13])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH2:16]([O:23][C:24]1[CH:25]=[CH:26][C:27]2[O:31][CH:30]([CH2:32]Br)[CH2:29][C:28]=2[CH:34]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2([OH:13])[CH2:8][CH2:9][N:10]([CH2:32][CH:30]3[CH2:29][C:28]4[CH:34]=[C:24]([O:23][CH2:16][C:17]5[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=5)[CH:25]=[CH:26][C:27]=4[O:31]3)[CH2:11][CH2:12]2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 104886244-[(4-Fluorophenyl)methyl]piperidin-4-olHCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran

Product 1

HCID 22628415(RS)-4-(4-Fluoro-benzyl)-1-(5-benzyloxy-2 3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

Procedure

The title compound MS: m/e=448.6 (M+H+) was prepared from 4-(4-fluoro-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-7c01330852b247e899ccc74cc011ac45
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

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