(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → (RS)-4-(4-Ethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

HRID 278425Notes

Reaction equation

HRID 278425 reaction equation
[CH2:1]([C:3]1[CH:16]=[CH:15][C:6]([CH2:7][C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1)[CH3:2].[CH2:17]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][CH:31]([CH2:33]Br)[CH2:30][C:29]=2[CH:35]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][C:8]2([OH:14])[CH2:9][CH2:10][N:11]([CH2:33][CH:31]3[CH2:30][C:29]4[CH:35]=[C:25]([O:24][CH2:17][C:18]5[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=5)[CH:26]=[CH:27][C:28]=4[O:32]3)[CH2:12][CH2:13]2)=[CH:15][CH:16]=1)[CH3:2]

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 226284084-[(4-Ethylphenyl)methyl]piperidin-4-ol

Product 1

HCID 22628361(RS)-4-(4-Ethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

Procedure

The title compound MS: m/e=458.6 (M+H+) was prepared from 4-(4-ethyl-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-9d4efb84232d4147ac9d7be429e6601c
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

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