(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → HCID 22628373, compound

HRID 278428Notes

Reaction equation

HRID 278428 reaction equation
[F:1][C:2]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:3]=1[CH2:4][C:5]1([OH:11])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1.[CH2:17]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][CH:31]([CH2:33]Br)[CH2:30][C:29]=2[CH:35]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:1][C:2]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:3]=1[CH2:4][C:5]1([OH:11])[CH2:10][CH2:9][N:8]([CH2:33][CH:31]2[CH2:30][C:29]3[CH:35]=[C:25]([O:24][CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:26]=[CH:27][C:28]=3[O:32]2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 22628379HCID 22628379, compound

Product 1

HCID 22628373HCID 22628373, compound

Procedure

The title compound MS: m/e=466.6 (M+H+) was prepared from 4-(2,4-difluoro-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-c26895702e50487e83c473f62dc89d79
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

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