(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → HCID 22628406, compound

HRID 278429Notes

Reaction equation

HRID 278429 reaction equation
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:17]=[CH:16][C:7]([CH2:8][C:9]2([OH:15])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1.[CH2:20]([O:27][C:28]1[CH:29]=[CH:30][C:31]2[O:35][CH:34]([CH2:36]Br)[CH2:33][C:32]=2[CH:38]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[F:19][C:2]([F:18])([F:1])[O:3][C:4]1[CH:17]=[CH:16][C:7]([CH2:8][C:9]2([OH:15])[CH2:14][CH2:13][N:12]([CH2:36][CH:34]3[CH2:33][C:32]4[CH:38]=[C:28]([O:27][CH2:20][C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=5)[CH:29]=[CH:30][C:31]=4[O:35]3)[CH2:11][CH2:10]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 22628405HCID 22628405, compound

Product 1

HCID 22628406HCID 22628406, compound

Procedure

The title compound MS: m/e=514.6 (M+H+) was prepared from 4-(4-trifluoromethoxy-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-d0727fd686314cfdae4a276ce8827e9b
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

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