(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → HCID 22628352, compound

HRID 278430Notes

Reaction equation

HRID 278430 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[CH2:6][C:7]1([OH:13])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]2[O:34][CH:33]([CH2:35]Br)[CH2:32][C:31]=2[CH:37]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[CH2:6][C:7]1([OH:13])[CH2:8][CH2:9][N:10]([CH2:35][CH:33]2[CH2:32][C:31]3[CH:37]=[C:27]([O:26][CH2:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:28]=[CH:29][C:30]=3[O:34]2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 22628417HCID 22628417, compound

Product 1

HCID 22628352HCID 22628352, compound

Procedure

The title compound MS: m/e=498.6 (M+H+) was prepared from 4-(3-trifluoromethyl-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.

Sources & evidence

ORD record
ord-ca6e7b51fd334d128f2e25d8227ad0fd
Source dataset
uspto-grants-2002_03
Patent number
US06359138B1

Reaction notes

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