(2S,3S)-2-benzyloxy-5-(1-naphthyl)pentan-3-ol → methyl 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxylate

HRID 278487Notes

Reaction equation

HRID 278487 reaction equation
[CH2:1]([O:8][C@H:9]([C@@H:11](O)[CH2:12][CH2:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:25]1[CH:29]=[C:28]([C:30]([O:32][CH3:33])=[O:31])[N:27]=[CH:26]1>>[CH2:1]([O:8][C@H:9]([C@H:11]([N:25]1[CH:29]=[C:28]([C:30]([O:32][CH3:33])=[O:31])[N:27]=[CH:26]1)[CH2:12][CH2:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][CH:15]=1)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 57094200(2S,3S)-2-benzyloxy-5-(1-naphthyl)pentan-3-olHCID 178418785HCID 178418785, compound

Product 1

HCID 69690219methyl 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxylate

Procedure

Methyl 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]-imidazole-4-carboxylate was prepared from (2S,3S)-2-benzyloxy-5-(1-naphthyl)pentan-3-ol (obtained in Preparation 26) and methyl imidazole-4-carboxylate.

Sources & evidence

ORD record
ord-fa7c39864f024e18a30b2ff28a6cbbb9
Source dataset
uspto-grants-2002_03
Patent number
US06359145B1

Reaction notes

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