HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 278495Generated: October 30, 2026
Ammonium Hydroxide → 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxamide
https://huagongshe.com/reaction/278495
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | methyl 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxylate | HCID 69690219 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxamide | HCID 57324110 | 93.3% |
Reaction Steps
A mixture of methyl 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxylate (obtained in Example 3(20)) (160 mg) in ammonium hydroxide (10 ml) and DMF (5 ml) was heated at 100° C. for 8 h in a sealed tube and then concentrated in vacuo. Flash chromatography (dichloromethane:methanol=20:1) gave 1-[(2S,3R)-2-benzyloxy-5-(1-naphthyl)-3-pentyl]imidazole-4-carboxamide (144 mg, 93.3%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06359145B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-8f389dc6e1014af0878d0cefa547b947 |
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| Source note | uspto-grants-2002_03 |
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