Methanol → HCID 12970023, compound

Participants

Reaction Steps

A mixture of 1-[(2S,3R)-2-(benzyloxy)-5-(2-chlorophenyl)-3-pentyl]imidazole-4-carboxamide (obtained in Example 3(9))(40 mg) and iodotrimethylsilane (0.02 ml) in chloroform (1 ml) was stirred at room temperature for 2 hours. The mixture was poured into methanol and the whole was evaporated in vacuo. The residue was taken up in ethyl acetate, washed with water, aqueous sodium bisulfite and sodium bicarbonate, successively, and dried. The residue left after evaporation of solvent was purified by column chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (20:1) to give a white powder of 1-[(2S,3R)-2-hydroxy-5-(2-chlorophenyl)-3-pentyl]imidazole-4-carboxamide (6.1 mg).

Provenance & Evidence