反应详情

To a solution of the obtained methyl 5-(4-pyridyl)-2-thiophenecarboxylate (410 mg) in ethanol (20 ml) was added 1 N sodium hydroxide solution (4 ml) and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated, and the residue was dissolved in water, to which was added 1 N hydrochloric acid (4 ml). The precipitate was filtered, washed with water and dried to give the title compound (363 mg).

1. concentrationThe reaction solution was concentrated
2. dissolutionthe residue was dissolved in water, to which
3. additionwas added 1 N hydrochloric acid (4 ml)
4. filtrationThe precipitate was filtered
5. washwashed with water
6. customdried