HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Pyridyl)-4-methylthiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-methyl-2-(pyridin-4-yl)-1,3-thiazole-5-carboxylate | HCID 619089 | — |
| Reactant | 2-(Oxolan-2-yl)ethan-1-ol | HCID 11989572 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Pyridyl)-4-methylthiazole-5-carboxylic acid | HCID 1483713 | 90.2% |
Reaction Steps
A mixture of ethyl 4-methyl-2-(4-pyridyl)thiazole-5-carboxylate (744 mg), 1 N NaOH (4 ml) and tetrahydrofuran-ethanol (1:1, 6 ml) was stirred at room temperature for 1 hour and diluted with water, to which was added 1 N hydrochloric acid (4 ml) to give the title compound as crystals (595 mg, 90.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06359134B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-25cf9bce5db940d682c21e88c8adc033 |
| Source note | uspto-grants-2002_03 |