反应详情

To a mixture of 1-(tert-butoxycarbonyl)piperazine (3.72 g), 4-methyl-2-(4-pyridyl) -5-thiazolecarboxylic acid (4.4 g), triethylamine (2.5 g) and HOBt (2.7 g) in DMF (60 ml), was added WSC hydrochloride (4.217 g) under ice-cooling and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated, and to the residue were added dichloromethane and sodium bicarbonate aqueous solution. The organic layer was separated, washed with water and brine, dried and concentrated. The residue was purified with silica gel chromatography (dichloromethane:methanol=50:1) to give colorless crystals of the title compound (6.49 g).

1. temperaturecooling
2. concentrationThe reaction solution was concentrated
3. additionto the residue were added dichloromethane and sodium bicarbonate aqueous solution
4. customThe organic layer was separated
5. washwashed with water and brine
6. customdried
7. concentrationconcentrated
8. customThe residue was purified with silica gel chromatography (dichloromethane:methanol=50:1)