HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N,O-dimethyl-N-(1-trityl-piperidine-4-carbonyl)hydroxylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 1-Tritylpiperidine-4-carboxylic acid | HCID 20520182 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N,O-dimethyl-N-(1-trityl-piperidine-4-carbonyl)hydroxylamine | HCID 22628088 | — |
Reaction Steps
To a mixture of 1-tritylpiperidine-4-carboxylic acid (7.0 g), O,N-dimethylhydroxylamine hydrochloride (2.0 g) and triethylamine (2.9 ml) in dichloromethane (70 ml) was added WSC (3.97 g), and the mixture was stirred at room temperature for 1 hour and concentrated. To the residue was added ethyl acetate, and the mixture was washed with water, dried (MgSO4) and concentrated. The resulting crystals (6.3 g) were washed with isopropylether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06359134B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-13e3f414752049a18edaff60a4782d74 |
| Source note | uspto-grants-2002_03 |