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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 278575Generated: October 30, 2026

Hydrochloric Acid → HCID 22628122, compound

https://huagongshe.com/reaction/278575

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 22628040HCID 22628040—
SolventTetrahydrofuran ethanolHCID 21873804—
ProductHCID 22628122HCID 2262812290.9%

Reaction Conditions

Temperature70 °C

Reaction Steps

A mixture of ethyl 2-(2-tert-butoxycarbonylamino-5-pyridyl)-4-methyl-5-thiazolecarboxylate (180 mg), 1N NaOH (2 ml) and EtOH-THF (2:1, 6 ml) was stirred at 70° C. for 1 hour, to which was added 1 N HCl (2 ml) to give the title compound (151 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06359134B1
Source datasetuspto-grants-2002_03
ORD IDord-4d1673e0bdf846b187f74d59926bbe3c
Source noteuspto-grants-2002_03