Boron tribromide → HCID 22628243, compound

Participants

Reaction Steps

According to a similar method described in Working Example 36, to a solution of 1-(4-diisopropylaminomethylbenzoyl)-4-(7-methoxynaphthalene-2-sulfonyl)piperazine (150 mg) in CH2Cl2 (6 ml) was added dropwise at 0° C. a solution of 3.5 M BBr3 in CH2Cl2 (0.18 ml), and the solution was stirred at room temperature for 1 hour. To the reaction solution was added sodium bicarbonate solution and the organic layer was separated, dried and concentrated to give a colorless solid of the title compound (119 mg).

Provenance & Evidence