HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 278606Generated: October 27, 2026
Tetrahydrofuran → HCID 178454285, compound
https://huagongshe.com/reaction/278606
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-DI-Boc-2-methylisothiourea | HCID 546603 | — |
| Reactant | HCID 22628032 | HCID 22628032 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178454285 | HCID 178454285 | 53.9% |
Reaction Steps
To a solution of 1-(4-aminocyclohexane-1-ylcarbonyl)-4-(6-chloronaphthalene-2-sulfonyl)piperazine hydrochloride (220 mg) and triethylamine (232 mg) in methanol (10 ml)-tetrahydrofuran (10 ml) was added N,N′-di-tert-butoxycarbonyl-S-methylisothiourea (135 mg) and the solution was stirred at 40° C. for 24 hours. The reaction solution was concentrated, and the residue was purified with silica gel column chromatography (hexane:ethyl acetate=1:2) to give a colorless solid of the title compound (170 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06359134B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-d99fb77d2f9e481cb38786f671bd0808 |
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| Source note | uspto-grants-2002_03 |
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