Sodium Hydroxide → HCID 22628009, compound

HRID 278611Notes

Reaction equation

HRID 278611 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:27][C:26]([C:28]4[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=4)=[N:25][C:24]=3[CH3:34])=[O:22])[CH:17]([C:35]([O:37]CC)=[O:36])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:27][C:26]([C:28]4[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=4)=[N:25][C:24]=3[CH3:34])=[O:22])[CH:17]([C:35]([OH:37])=[O:36])[CH2:16]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22627972HCID 22627972, compound

Product 1

HCID 22628009HCID 22628009, compoundYield 17.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of ethyl 4-(6-chloronaphthalene-2-sulfonyl)-1-[4-methyl-2-(4-pyridyl)-5-thiazolecarbonyl]-piperazine-2-carboxylate (100 mg) in methanol (20 ml) was added 1 N sodium hydroxide aqueous solution (5 ml), and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, and 1 N hydrochloric acid aqueous solution (5 ml) was added to the residue. The precipitate was filtered and dried to give a colorless solid of the title compound (17 mg).

Workup

  1. concentrationThe reaction solution was concentrated
  2. addition1 N hydrochloric acid aqueous solution (5 ml) was added to the residue
  3. filtrationThe precipitate was filtered
  4. customdried

Sources & evidence

ORD record
ord-018ecd3085ed43b4ad256abc9928d883
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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