HCID 22628136, compound → HCID 22628216, compound

Participants

Reaction Steps

To a solution of 1-[4-(1-imidazolyl)benzoyl]-4-[6-(2,2,2-trichloroethoxycarbonylamino)naphthalene-2-sulfonyl]piperazine (400 mg) in acetic acid (5 ml) was added zinc powder (1 g), and the mixture was stirred at room temperature for 1 day. The reaction solution was filtered, and the filtrate was concentrated. The residue was dissolved in 0.5 N hydrochloric acid, washed with ethyl acetate and made alkaline with 1 N sodium hydroxide aqueous solution. The precipitate was collected by filtration, washed with water and dried to give a colorless solid of the title compound (187 mg).

Provenance & Evidence