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HRID278662

反应详情

EQUATION

反应方程式

HRID 278662 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CC(C)(C)O3)cc1F
HCID69548883

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CC1(C)CC(C)(C)c2cc(C#Cc3ccc(C(=O)O)c(F)c3)ccc2O1
HCID9903139

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Following general procedure L and using 2-fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid methyl ester (Compound 29, 0.14 g, 0.4 mmol), 5 mL of methanol and 1M sodium hydroxide solution (2 mL) followed by recrystallization from ethyl acetate, the title compound was obtained (0.083 g, 58%).

WORKUP

后处理

  1. customfollowed by recrystallization from ethyl acetate