HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(1-Benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane | HCID 22568833 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene | HCID 22568983 | — |
Reaction Steps
Using General Procedure E; [4-(1-benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane (Intermediate 89, 240 mg, 0.69 mmol) in methanol (6 mL) was treated with potassium carbonate (10.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (190 mg, 99%) was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06359135B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-b78c5b256eb9496c83cc51667209d886 |
| Source note | uspto-grants-2002_03 |