反应详情

11.2 g (0.1 moles) 4-mercaptopyrimidine is dissolved in 100 ml ethanol containing 10.8 g sodium methoxide. 18 g (0.1 moles) 3-chloromethylpyridine-N-oxide hydrochloride is added; the mixture is heated under reflux for about one hours. The solution is cooled to ambient temperature, the sodium chloride filtered off, and the filtrate evaporated under vacuum to eliminate the solvent. The residue is crystallized from ethyl acetate to give 15.35 g of product (M.P.=105°-108° C.; yield=70%).

1. temperaturethe mixture is heated
2. temperatureunder reflux for about one hours
3. filtrationthe sodium chloride filtered off
4. customthe filtrate evaporated under vacuum
5. customThe residue is crystallized from ethyl acetate