Glycerol → Quinoxaline-2-carboxylic acid

HRID 278840ノート

反応式

HRID 278840 の反応式
[O:1]=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.O[CH2:14][CH:15]([CH2:17][OH:18])O.CC1C=[N:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=1>CS(C)=O>[N:28]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=[CH:14][C:15]=1[C:17]([OH:18])=[O:1]

参加物

5

反応物 3

HCID 753GlycerolHCID 236862-MethylquinoxalineHCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

生成物 1

HCID 96695Quinoxaline-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Cells of various microorganisms were grown in the tubes containing 2.5 mL of the dextrose, nutrisoy flour medium as described in EXAMPLE I. Individual tubes were inoculated with spores or vegetative cells (about 1% v/v of spore or vegetative cell stock culture) of various microorganisms stored as frozen glycerol suspensions, and incubated at about 29° C. with agitation (210 rpm) on a rotary shaker. After about 48 hours, 0.05 mL of a 10 mg/mL solution of 2-methylquinoxaline in DMSO was added to each tube. After about 4 days incubation, the contents of each tube were extracted, and the individual extracts were analyzed by HPLC as described in EXAMPLE I. The yields of 2-quinoxalinecarboxylic acid were determined by HPLC and the results are summarized in TABLE 5.

後処理

  1. customincubated at about 29° C. with agitation (210 rpm) on a rotary shaker
  2. waitAfter about 4 days incubation
  3. extractionthe contents of each tube were extracted

出典と根拠

ORDレコード
ord-daf9265430af4cd7a6b0be1ad40ff818
出典データセット
uspto-grants-2002_03
特許番号
US06361979B1

反応ノート

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