Glycerol → Quinoxaline-2-carboxylic acid

HRID 278840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 278840
[O:1]=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.O[CH2:14][CH:15]([CH2:17][OH:18])O.CC1C=[N:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=1>CS(C)=O>[N:28]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=[CH:14][C:15]=1[C:17]([OH:18])=[O:1]

Komponenten

5

Edukt 3

HCID 753GlycerolHCID 236862-MethylquinoxalineHCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal

Produkt 1

HCID 96695Quinoxaline-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Cells of various microorganisms were grown in the tubes containing 2.5 mL of the dextrose, nutrisoy flour medium as described in EXAMPLE I. Individual tubes were inoculated with spores or vegetative cells (about 1% v/v of spore or vegetative cell stock culture) of various microorganisms stored as frozen glycerol suspensions, and incubated at about 29° C. with agitation (210 rpm) on a rotary shaker. After about 48 hours, 0.05 mL of a 10 mg/mL solution of 2-methylquinoxaline in DMSO was added to each tube. After about 4 days incubation, the contents of each tube were extracted, and the individual extracts were analyzed by HPLC as described in EXAMPLE I. The yields of 2-quinoxalinecarboxylic acid were determined by HPLC and the results are summarized in TABLE 5.

Aufarbeitung

  1. customincubated at about 29° C. with agitation (210 rpm) on a rotary shaker
  2. waitAfter about 4 days incubation
  3. extractionthe contents of each tube were extracted

Quellen und Nachweise

ORD-Eintrag
ord-daf9265430af4cd7a6b0be1ad40ff818
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06361979B1

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