Methanol → HCID 86757899, compound

HRID 278909Notes

Reaction equation

HRID 278909 reaction equation
[N+](C1C=CC([O:10][C:11]([N:13]2[C:18](=[O:19])[CH2:17][O:16][CH:15]([CH3:20])[CH:14]2[C:21]2[CH:26]=[CH:25][C:24]([F:27])=[C:23]([F:28])[CH:22]=2)=[O:12])=CC=1)([O-])=O.CO>C(Cl)Cl>[F:28][C:23]1[CH:22]=[C:21]([CH:14]2[CH:15]([CH3:20])[O:16][CH2:17][C:18](=[O:19])[N:13]2[C:11]([OH:12])=[O:10])[CH:26]=[CH:25][C:24]=1[F:27]

Participants

4

Reactant 2

HCID 887MethanolHCID 18623244HCID 18623244, compound

Product 1

HCID 86757899HCID 86757899, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(3,4-Difluorophenyl)-2-methyl-5-oxo-morpholine-4-carboxylic acid-4-nitro-phenyl ester (section II, part 1) was coupled to 3-[4-(cyano-4-phenyl-piperidin-1-yl]-propylamine in the same manner as described in section I, part 3c. White powder. M.P.=191-194° C.; Mass spec. 497 (M+1, 100%); [α]D=+23.1 (c=0.09, MeOH) Analysis calculated for C33H36N3O4F2Cl.0.35 CH2Cl2: C, 58.38; H, 5.68; N, 9.96. Found: C, 58.57; H, 6.03; N, 9.72.

Sources & evidence

ORD record
ord-1527b91f51494d839dd5b1591360a44c
Source dataset
uspto-grants-2002_03
Patent number
US06362182B1

Reaction notes

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